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Immortalization of rat embryo fibroblasts by mutant polyomavirus large T antigens deficient in DNA binding. A Cowie , J de Villiers and R Kamen ABSTRACT We have identified a putative DNA-binding domain in polyomavirus large T antigen. Mutations introduced into the gene between amino acids 290 and...
Multiple hormone-inducible enhancers as mediators of differential transcription. M G Toohey , K L Morley and D O Peterson ABSTRACT Sets of genes under a common regulatory control in a given cell type are often differentially transcribed. The possibility that this differential transcription can be...
Human proto-oncogene N-myc encodes nuclear proteins that bind DNA. G Ramsay , L Stanton , M Schwab and J M Bishop ABSTRACT N-myc is a gene whose amplification has been implicated in the genesis of several malignant human tumors. We have identified two proteins with molecular weights of 65,000 and...
Structure of the Saccharomyces cerevisiae HO gene and analysis of its upstream regulatory region. D W Russell , R Jensen , M J Zoller , J Burke , B Errede , M Smith and I Herskowitz ABSTRACT The HO gene product of Saccharomyces cerevisiae is a site-specific endonuclease that initiates mating type...
Multiple regulatory genes control expression of a gene family during development of Dictyostelium discoideum. S Alexander , A M Cibulsky and S D Cuneo ABSTRACT Mutant strains of Dictyostelium discoideum carrying dis mutations fail to transcribe specifically the family of developmentally regulated...