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Objective To estimate the relative influence of input pressure and arteriole rarefaction on gastrocnemius muscle perfusion in patients with PAD after exercise and/or percutaneous interventions. Methods A computational network model of the gastrocnemius muscle microcirculation was adapted to...
Insulin is a vasoactive hormone that regulates vascular homeostasis by maintaining balance of endothelial‐derived NO and ET‐1. Although there is general agreement that insulin resistance and the associated hyperinsulinemia disturb this balance, the vascular consequences for hyperinsulinemia...
Objective E2 enhances vasodilation in healthy women, but vascular effects of the phytoestrogen GEN are still under investigation. IR compromises microvascular function. We therefore examined the interaction of E2, GEN, and IR on microvascular vasodilatory responsiveness. Methods We hypothesized...
Objectives This study performed skin‐surface LDF measurements and SampEn analysis with the aims of (i) capturing the temporal complexity of cerebral hemodynamics in stroke patients and (ii) discriminating stroke patients from healthy control subjects. We also investigated the response induced...
Objective The aim of the present study was to investigate the in vivo protective effects of hesperidin or diosmin or apigenin on damage induced by transient BCCAO and reperfusion. Methods Rat pial microcirculation was observed through a closed cranial window, using fluorescence microscopy. Pial...
Objectives To quantify how incremental capillary PL, such as that seen in experimental models of sepsis, affects tissue oxygenation using a computation model of oxygen transport. Methods A computational model was applied to capillary networks with dimensions 84 × 168 × 342 (NI) and 70 × 157 ×...
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