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To overcome the many hurdles preventing the use of antiviral and anticancer nucleosides as therapeutics, the development of a prodrug methodology (i.e., pronucleotide) for the in vivo delivery of nucleotides has been proposed as a solution. The ideal pronucleotide should be non‐toxic, stable in...
Peptidylprolyl isomerases (PPIases) are a group of cytosolic enzymes first characterized by their ability to catalyze the cis–trans isomerization of cis‐peptidylprolyl bonds. Subsequently, some PPIases were also identified as the initial targets of the immunosuppressant drugs—cyclosporin A...
An efficient method is described for preparation of diltiazem hydrochloride (Herbesser®), a marketed calcium antagonist widely used for the treatment of ischemic heart disease. In the reaction of 2‐nitrothiophenol (1) with trans‐3‐phenylglycidic esters (2) carrying various substituents on...
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