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L-asparaginase is widely used in the treatment of acute lymphoblastic leukemia (ALL). It induces an inhibition of synthesis of many proteins, among them most of those involved in blood coagulation and fibrinolysis. The alterations of the hemostatic system are rather complex, consisting of a...
Although in the last years new insights have been gained into the biology of multiple myeloma (MM), therapeutic progress has been modest since the introduction of alkylating agents (usually melphalan and cyclophosphamide) nearly three decades ago. With few exceptions, a large number of clinical...
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