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You can now keep track of new articles from Journal of the Society for Gynecologic Investigation on your personalized homepage!
OBJECTIVE: We present current concepts and assess the quality of information available for the prevention of cardiovascular disease in women. METHODS: This article reviews research bearing on the prevention of cardiovascular disease in women, with particular attention to modifiable risk factors....
OBJECTIVE: We sought to determine the origin of two prenatal cases of chromosome 21 rear rangements not amenable to clarification by conventional cytogenetic methodology. METHODS: Hypervariable repeat polymorphisms (chromosome 21) were used to determine the type of structural rearrangement and...
OBJECTIVE: We assessed insulin sensitivity in women comparing the insulin tolerance test (ITT) with the intravenous glucose tolerance test with frequent sampling and computer modeling (FSIVGTT) and evaluated the effects ofhormonal therapy in postmenopausal women using both methods. METHODS: This...
OBJECTIVE: To determine whether women with two or more previous spontaneous abortions of unknown etiology, by conventional testing criteria, have a different rate of subsequent fetal loss than controls after ultrasonic documentation of fetal cardiac activity. METHODS: Medical records were...
OBJECTIVE: The purpose of these studies was to determine the effects of the essential fatty acid, linoleic acid, and the commonly used non-steroidal anti-inflammatory agents, aspirin and acet aminophen, on the rate of prostaglandin (PG) biosynthesis by human amnion cells. METHODS: Amnion cells...
OBJECTIVE: We reviewed the evidence for an intrinsic ovarian renin-angiotensin system (OVRAS), highlighting potential diverse signaling in this system through different bioactive angiotensin peptides, their specific receptors, and second messengers. In addition, sites of action for O VRAS in the...
OBJECTIVE: 17β estradiol dehydrogenase (17βDH) is a model for pyridine-dependent steroid- converting enzymes. To define the structural and functional parameters of 17βDH, we created an expression system for production of abundant, homogeneous enzyme. METHODS: A full-length 17βDH cDNA clone...
OBJECTIVE: This study determined levels of cathepsin D activity in tissue components of normal human ovary to establish a basis for comparison with human ovarian adenocarcinomas. METHODS: Cathepsin D activity per mg tissue, per μ g protein, and per μg DNA was determined in human ovarian tissues...
OBJECTIVE : We explored the role of the BCL-2 proto-oncogene in the life cycle of trophoblast cells by examining: 1) the patterns of BCL-2 expression in normal placenta at various gestational ages and in specimens of hydatidiform moles and choriocarcinomas, and 2) the effects of cyclic adenosine...
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