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Objectives. Experiments were designed to determine whether coronary endothelial dysfunction after cardiac global ischemia and reperfusion could be prevented by warm blood cardioplegic solution. Background. The coronary endothelium produces endothelium-derived relaxing factor (EDRF) to prevent...
Objectives. The aims of the study were to 1) assess the effects of 12 weeks of exercise training at low work loads (i.e., corresponding to ≤50% of peak oxygen consumption (V o 2 )) on peak V o 2 and hyperemic calf blood flow in patients with severe congestive heart failure; and 2) evaluate left...
Objectives. The aim of this study was to examine the left ventricular mechanoenergetic effects of a novel Ca 2+ sensitizing agent, MCI-154, on diseased human hearts compared with dobutamine. Background. Unlike conventional cardiotonic agents, a Ca 2+ sensitizer that could produce a positive...
Objectives. We studied the hypothesis that in the absence of vascular pathology, coronary artery vasospasm occurs as a result of local regions of vascular muscle hyperreactivity. We aimed to explore the basis for a functional etiology of those vasospasms not explained on a structural basis....
Objectives. This study assessed the influence of donor age and preexisting donor coronary artery disease on the later development of allograft coronary artery disease, ischemic events and overall survival. Background. The increasing demand for heart donors has led to a tendency to liberalize age...
Objectives. The goal of this study was to evaluate clinical and autonomic variables (heart rate variability and baroreflex sensitivity) related to hemodynamic tolerability of VT in patients with sustained monomorphic VT and a healed myocardial infarction. Background. Sustained ventricular...
Objectives. We studied the clinical and genetic features of familial hypertrophic cardiomyopathy (FHC) caused by an Asp175Asn mutation in the alpha-tropomyosin gene in affected subjects from three unrelated families. Background. Correlation of genotype and phenotype has provided important...
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