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This experiment examined the effects of two sedative/anxiolytic drugs, diazepam and clonidine, on the eyeblink component of the acoustic startle response in healthy volunteers. Twelve males (18-30 years), screened for normal hearing thresholds, participated in three sessions in which they...
We previously reported that, in rats chronically treated with the antidepressant drug imipramine, the enhanced locomotor response to the D 2 -like receptor agonist quinpirole became less sensitive to the inhibitory effect of the D 1 receptor antagonist SCH 23390 and more sensitive to the...
Anabolic-androgenic steroids (AAS) are used by athletes to enhance performance and physique. Case reports and observations propose that AAS have mood elevating properties and that chronic use leads to addiction. The aim of this study was to evaluate the subjective and physiological effects of...
A case is reported of a 20-year-old female student who had been abusing carbamazepine with alcohol and described a resulting sense of euphoria. The literature is reviewed for evidence to support this claim, and possible mechanisms to account for the euphorigenic effect of alcohol and...
The behavioural effects of selective serotonin reuptake inhibitors (paroxetine, sertraline, citalopram, fluvoxamine, fluoxetine) and reference compounds (N,N'-di( o -tolyl)guanidine, haloperidol, 3-(3-hydroxyphenyl)- N-(1-propyl)piperidine and chlorpromazine) were studied for their ability to...
There is a high incidence of sexual dysfunction in the general population and sexual dysfunction is often an integral symptom of a depressive disorder. In addition, all antidepressants have effects on sexual functioning, as the result of side-effects of these medications and as a reflection of...
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