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The electrocardiographic effects of clovoxamine, an antidepressant that inhibits the neuronal uptake of both noradrenaline and 5-hydroxytryptamine, have been studied. High speed electrocardiograms were recorded on 28 patients with depressive illness before and after 4 weeks treatment with either...
It can be extremely difficult to interpret the results of experiments in which a treatment is found to antagonize the behavioural effects of a drug. This article discusses strategies that can be used to help identify the nature of the antagonism and examines what such experiments tell us about...
The pharmacological profile of the two 5-HT 3 (5-hydroxytryptamine) receptor antagonists, the putative anxiolytics ICS 205-930 and GR38032F was compared with that of diazepam in four standard behavioural tests in rats. All the investigated drugs induced an anxiolytic effect in the passive...
The 5-HT 1A receptor agonist 8-hydroxy-2-(di- n -propylamino)tetralin (8-OH-DPAT), 0.1 mg/kg -1 subcutaneously, produced a suppression of horizontal ('locomotion') and vertical ('rearing') activity, in an open field arena. This effect was partially antagonized by treatment with (-)pindolol, 2...
The interaction between tyramine and the new short-acting and reversible mono amine oxidase inhibitor moclobemide was investigated in a double-blind placebo-controlled study in six healthy volunteers. There were two consecutive study periods of 8 days during which the subjects received...
Functional responsiveness to 5-HTP (L-5-hydroxytryptophan) and quipazine 24 h after one single dose and 24 h and 72 h after repeated administration (2.5 and 10 mg/kg twice daily for 7 days) of maprotiline, oxaprotiline and its (+) and (-) enantiomers was tested in the rat. All compounds markedly...
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