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Both stress response and antidepressant drug action may be mediated by beta-adrenergic receptors (βAR). Since learned helplessness is a stress-induced animal model of depression, βAR are relevant to investigate in this model. To date, studies have measured changes in total receptor density (R T...
In Alzheimer's disease (AD), SPECT imaging of regional cerebral blood flow (rCBF) has emphasized deficits in the posterior association cortex. Previous studies have shown an association between these deficits and cognitive performance, both on overall cognitive tests and more specific tests such...
Pre-clinical and some clinical evidence suggests that central overdrive within the hypothalamic-pituitary-adrenal (HPA) axis may play a role in panic disorder, and that the anti-panic efficacy of alprazolam may involve its ability to inhibit this drive. Detailed examination of 24 h secretion of...
Data were obtained from 46 healthy volunteers, 16 males and 30 females, lumbar punctured at the L4–5 level without strict bedrest prior to puncture. 18 ml of CSF was collected at the puncture, which was performed with a 0.9 mm diameter needle. Contradictory to previous reports, body height did...
The effect of 17β-estradiol (E 2 ) on the response of dopamine (DA) and serotonin (5-HT) to acute lithium in the brains of ovariectomized rats was investigated. An E 2 injection (100 ng/s.c.) to ovariectomized rats did not change striatal DA levels, whereas the levels of its metabolites,...
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