Select All | Select None
You can now keep track of new articles from Journal of Pharmacology and Experimental Therapeutics on your personalized homepage!
Abstract Cisplatin cis -diamminedichloroplatinum(II) is a widely used antitumor drug with dose-limiting nephrotoxic side effects due to selective toxicity to the proximal tubule. In the present study, the chemoprotective potential of three selenocysteine Se -conjugates, Se -methyl- l...
Abstract Ribonucleases (RNases) possess a variety of biological activities and, under certain conditions, are deleterious. Hence, design of selective inhibitors has been suggested as a strategy for treating RNase-related disorders. In the present study, isothermal titration calorimetry was used...
Abstract Dopamine D1 receptors within the nucleus accumbens (NAc) are intricately involved in the rewarding effects of cocaine and in withdrawal symptoms after cessation of repeated cocaine administration. These receptors couple to a variety of ion channels to modulate neuronal excitability....
Abstract The present study investigated the effect of the selective cannabinoid agonist, WIN 55212-2 (4,5-dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6 H -pyrrolo3,2,1ijquinolin-6-one, on body temperature. WIN 55212-2 (1, 2.5, 5, and 10 mg/kg, i.m.) induced hypothermia in...
Abstract To explore the feasibility of drug delivery to the liver by the use of adenovirus-mediated human oligopeptide transporter (hPEPT1) gene transfer, we examined the accumulation of l - 3 Hcarnosine in the hepatoma cell line (HepG2 and WIFB9) and mouse liver. We constructed a recombinant...
Abstract Human obesity may be caused by a resistance to circulating leptin. Evidence from rodents and humans suggests that a major component of this resistance is an impairment in the ability of the blood-brain barrier (BBB) to transport leptin from the blood to the brain. One potential way to...
Abstract The disposition kinetics of six cationic drugs in perfused diseased and normal rat livers were determined by multiple indicator dilution and related to the drug physicochemical properties and liver histopathology. A carbon tetrachloride (CCl 4 )-induced acute hepatocellular injury model...
Abstract Using intestinal monolayers, we showed that F-actin cytoskeletal stabilization and Ca 2+ normalization contribute to epidermal growth factor (EGF)-mediated protection against oxidant injury. However, the intracellular mediator responsible for these protective effects remains unknown....
Abstract We have synthesized a prodrug of the angiotensin-converting enzyme (ACE) inhibitor captopril by coupling this drug covalently to the low molecular weight protein (LMWP) lysozyme. Such drug-LMWP conjugates can be used for renal drug delivery, since LMWPs accumulate specifically in the...
Abstract The structure of the S (−)-nicotine molecule was modified via N - n -alkylation of the pyridine- N atom to afford a series of N - n -alkylnicotinium iodide salts with carbon chain lengths varying between C 1 and C 12 . The ability of these analogs to evoke 3 H overflow and inhibit S...
results per page
Save this article to read later. You can see your Read Later on your DeepDyve homepage.
To save an article, log in first, or sign up for a DeepDyve account if you don't already have one.
Sign Up Log In
To subscribe to email alerts, please log in first, or sign up for a DeepDyve account if you don't already have one.
Read and print from thousands of top scholarly journals.
Sign up with Facebook
Sign up with Google
Already have an account? Log in
To get new article updates from a journal on your personalized homepage, please log in first, or sign up for a DeepDyve account if you don't already have one.