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Abstract The transport step for p -aminohippurate (PAH) from cell to lumen across the luminal membrane of rabbit proximal tubules has not been adequately defined. To examine this process more closely, we determined the effects of possible transport inhibitors and substitutes for chloride on PAH...
Abstract The present study examined the effect of chronic hypoxia on coupling efficiency of alpha -1 adrenoceptors to inositol 1,4,5-trisphosphate (InsP 3 ) signaling in ovine uterine artery. Chronic hypoxia did not change the time course of InsP 3 formation, but significantly decreased the...
Abstract Posthypoxic myoclonus and seizures precipitate as secondary neurological consequences in ischemic/hypoxic insults of the central nervous system. Neuronal hyperexcitation may be due to excessive activation of glutamatergic neurotransmission, an effect that has been shown to follow...
Abstract The hemodynamic effects of a 20% exchange-transfusion with different solutions of highly purified human hemoglobin A-zero (A 0 ) were evaluated. We compared unmodified hemoglobin with hemoglobin cross-linked with O -raffinose. Unmodified hemoglobin increased systemic vascular resistance...
Abstract TA-993, (−)- cis -3-acetoxy-5-(2-(dimethylamino)ethyl)-2,3-di-hydro-8-methyl-2-(4-methylphenyl)-1,5-benzothiazepin-4(5H)one maleate, a new 1,5-benzothiazepine derivative with l-cis configuration, has a unique and selective increasing action on limb blood flow with little influence on...
Abstract The environmental neurotoxicant methylmercury (MeHg) causes profound disruption of cerebellar function. Previous studies have shown that acute exposure to MeHg impairs synaptic transmission in both the peripheral and central nervous systems. However, the effects of MeHg on cerebellar...
Abstract Prostaglandin (PG) release in cells expressing constitutive cyclooxygenase-1 is known to be regulated by liberation of arachidonic acid by phospholipase A 2 followed by metabolism by cyclooxygenase. However, the relative contribution of phospholipase A 2 to the release of PGs in cells...
Abstract The anticonvulsant activity of inhibitors of monoamine oxidase (MAO) was reported early after the development of irreversible MAO inhibitors such as tranylcypromine, but was never clinically used because of the adverse effects of these compounds. The more recently developed reversible...
Abstract Sydnocarb (3-(β-phenylisopropyl)- N -phenylcarbamoylsydnonimine) is a psychostimulant in clinical practice in Russia as a primary and adjunct therapy for a host of psychiatric disorders, including schizophrenia and depression. It has been described as a stimulant with an addiction...
Abstract Individual differences in ethanol preference may be linked to differences in the functional activity of forebrain monoamine systems or their sensitivity to modification by ethanol. To test this hypothesis, basal extracellular concentrations of dopamine (DA) and serotonin (5-HT) in the...
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