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Abstract Methamphetamine (METH) is a powerful psychostimulant that produces dopaminergic neurotoxicity manifested by a decrease in the levels of dopamine, tyrosine hydroxylase activity and dopamine transporter (DAT) binding sites in the nigrostriatal system. We have recently reported that...
Abstract Dual angiotensin-converting enzyme (ACE)/neutral endopeptidase (NEP) inhibitors, by decreasing angiotensin-II production and by preventing the degradation of atrial natriuretic peptide (ANP), may be useful for the treatment of hypertension and congestive heart failure. The thiol...
Abstract The toxicity of a short-term exposure to tert -butylhydroperoxide in U937 cells was markedly reduced by chemically or experimentally induced respiratory deficiency. Rotenone mitigated the lethal effects of the hydroperoxide over the same concentration-range in which the complex I...
Abstract This study investigated whether short-term exposure to Escherichia coli lipopolysaccharide (LPS) elicits vasomotor dysfunction in skeletal muscle in vivo and, if so, whether perivascular mast cell proteases partly modulate this response. With intravital microscopy, we found that...
Abstract Corticosteroids influence neuron activity in the hippocampus through the activation of mineralocorticoid and glucocorticoid receptors. For example, corticosteroids modulate the responses elicited by the activation of several different neurotransmitter receptors on hippocampal pyramidal...
Abstract The purpose of our investigation was to characterize the relationships between the pharmacodynamics of synthetic opioids in vivo and the interaction at the mu -opioid receptor. The pharmacokinetics and pharmacodynamics were determined in vivo after a single i.v. infusion of 3.14 mg/kg...
Abstract Pentobarbital administered intracerebroventricularly to mice has been shown previously to inhibit the analgesic action of morphine given intrathecally. The purpose of the present study was to examine the proposal that this antianalgesic action was mediated spinally by cholecystokinin....
Abstract The purpose of this study was to investigate the role of extracellular Ca ++ influx via L-type and non-L-type Ca ++ channels in thromboxane A 2 receptor-mediated contraction. In intact rat aorta, U46619, a selective thromboxane A 2 receptor agonist, induced concentration-dependent...
Abstract Grepafloxacin (GPFX) has a comparatively greater hepatobiliary transport than other quinolone antibiotics. The biliary excretion mechanism of GPFX was investigated in a series of in vivo and in vitro studies with Sprague-Dawley rats and the mutant strain Eisai-hyperbilirubinemia rats...
Abstract This study investigated the modulatory effect of magnesium (Mg ++ ) on basal and agonist-stimulated intracellular free calcium (Ca ++ ) concentration (Ca ++ i ) in vascular smooth muscle cells from spontaneously hypertensive rats (SHR). Effects of increasing extracellular Mg ++...
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