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10.1002/jps.2600811209.abs A rapid, simple assay procedure was developed for simultaneous analysis of otilonium bromide, a smooth‐muscle relaxant, and diazepam in tablets containing 20 mg of otilonium bromide and 2 mg of diazepam (20:2 tablets) or 40 mg of otilonium bromide and 2 mg of diazepam...
10.1002/jps.2600811202.abs Thirteen bulk pharmaceutical preparations of spironolactone were examined by Fourier transform (FT)—Raman spectroscopy and by diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) for residual solvents (including the hydrolysis product, thioacetic...
10.1002/jps.2600811207.abs The bioavailabilities of aged coprecipitates of griseofulvin (Gris), dimyristoylphosphatidylcholine (DMPC), or egg phosphatidylcholine (EPC) and cholesterol (CHOL) in rats and correlations with their in vitro dissolution behaviors were determined. In vivo absorption...
10.1002/jps.2600811203.abs Mannich bases were synthesized and converted to the corresponding arylhydrazones. X‐ray analysis of a ketone (1a) and a hydrazone (4d) revealed structural features of interest. All of the compounds showed cytotoxicity toward murine lymphocytic leukemia L1210 cells in...
10.1002/jps.2600811215.abs α‐Hydroxyaryl ketones such as 2‐hydroxypropiophenone and 1‐(2,4‐difluorophenyl)‐2‐hydroxy‐1‐propanone, the key intermediates in the preparation of antifungal agents, decompose into oxidized, rearranged, and condensed products. These products were...
10.1002/jps.2600811204.abs An in vitro testing method for measuring the release of nitroglycerin from topical drug products was evaluated. The method involved measuring the amount of nitroglycerin that diffused from ointments and patches through various synthetic membranes into receptor fluid...
10.1002/jps.2600811205.abs The geometry and structural features of the inclusion complexes of β‐cyclodextrin (β‐CD) with the chiral antiamnesic drugs (±)‐1‐benzyl‐4‐hydroxymethylpyrrolidin‐2‐one (WEB‐1868). (±)‐1‐benzenesulfonyl‐5‐ethoxypyrrolidin‐2‐one...
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