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10.1002/jps.2600780403.abs Four crystalline forms of ethynylestradiol solvates were obtained from three solvents (acetonitrile (Form A), methanol (Form B), and chloroform saturated with water (Forms C and D)), and were characterized by X‐ray powder patterns and thermal analyses. The crystal...
10.1002/jps.2600780404.abs The oral dose metabolism of dilazep dihydrochloride (tetrahydro‐1H‐1,4‐diazepine‐1,4(5H)‐dipropanol 3,4,5‐trimethoxybenzoate) was examined in six hypertensive patients receiving a single oral dose of 600 mg of dilazep (3–3.8 mg/kg BW). Blood was collected...
10.1002/jps.2600780407.abs The in vitro degradation of nitroglycerin (NTG) and its dinitrate metabolites in human blood and red blood cells (RBC) has been shown to exhibit apparent first‐order kinetics. The decay rates of NTG and its dinitrate metabolites, however, were dependent on the initial...
10.1002/jps.2600780408.abs The degree of hemolysis caused by the interaction between erythrocytes from various animals and emulsions stabilized with various lecithins was evaluated as a measure of the safety of emulsions for drug carriers. The stability of the emulsions was estimated using the...
10.1002/jps.2600780402.abs The synthesis of 2,3‐bis(2‐pyridyl)‐5,8‐quinoxalinediones has been carried out in order to provide new antitumor drugs related to streptonigrin. Some derivatives have been found to possess significant cytotoxic properties and their mechanism of action has been...
10.1002/jps.2600780406.abs The ultrastructural disposition of intra‐arterially administered adriamycin‐associated magnetic albumin microspheres has been investigated. The rat tail was used as the target organ and demarcated into the following three parts: T1, the injection site; T2, the...
10.1002/jps.2600780409.abs To evaluate the role of amphotericin B (AmB) in the biochemical modulation of antineoplastic agents, AmB was administered as a continuous infusion over a period of 52 to 120 h to 14 patients (26 courses) with advanced carcinomas. Continuous infusion amphotericin B...
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