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10.1002/jps.2600770616.abs In this study, methyl‐ and propylparaben flux from various alcohol donors through polydimethylsiloxane membranes was investigated. Flux from saturated alcohol vehicles was markedly increased relative to water and glycol systems. The uptake of neat alcohol, a measure...
10.1002/jps.2600770609.abs A previous report detailed the derivation and validation of an equation for calculating the Gibbs free energy of liquid‐solid adsorption via high‐performance liquid chromatography (HPLC). This study utilizes an improved form of that equation in conjunction with an...
10.1002/jps.2600770617.abs An electrochemical HPLC method for the simultaneous determination of haloperidol and reduced haloperidol in plasma is presented. Chlorohaloperidol serves as the internal standard. A cyanopropyl bond elut column was used for sample preparation. The eluate was evaporated...
10.1002/jps.2600770619.abs The dissociation constants, partition coefficients, and solubility of carbenoxolone (1) were determined using tritium‐labeled drug. The partition and solubility methods were used to assess the dissociation constants of carbenoxolone, while the pKa of the structurally...
10.1002/jps.2600770618.abs Charge transfer complexes between tryptamine: epinephrine, tryptamine: isoproterenol, tryptamine: catechol, and indole: catechol were demonstrated spectrophotometrically in aqueous solutions containing 0.1 M HCI. It was possible to make precise measurements and to...
10.1002/jps.2600770604.abs In order to quantitatively describe the peritoneal transport of drugs, this paper proposes a kinetic model that is based on the hydrodynamic pore theory of transcapillary exchange, and incorporates an explicit description of volume and osmolality changes in the...
10.1002/jps.2600770615.abs Fluconazole concentrations in biological fluids were determined by high‐performance gas chromatography. A simple extraction procedure with chloroform, under basic conditions and after the addition of UK‐47,265 as the internal standard and with no evaporation stage,...
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