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10.1002/jps.2600770512.abs Solid dispersions of a poorly water‐soluble drug (REV 5901; α‐pentyl‐3‐(2‐quinolinylmethoxy)benzenemethanol; 1) in an amphiphilic vehicle (Gelucire 44/14; 2) and in polyethylene glycol (PEG) 1000, PEG 1450, and PEG 8000 were prepared. The vehicle 2 was a...
10.1002/jps.2600770517.abs Interaction phenomena, in aqueous‐based hydroxypropyl methylcellulose (HPMC) and polyvinyl alcohol (PVA) film‐coating formulations containing water‐soluble additives (citric acid and urea) have been examined by thermal methods to assess glass transition,...
10.1002/jps.2600770509.abs Ceftriaxone binding in extravascular fluids and diluted plasma was characterized by equilibrium dialysis techniques and the data was subjected to Scatchard analysis. The extent of ceftriaxone binding in extravascular fluids (synovial, lymph, ascites, and pleural...
10.1002/jps.2600770515.abs The release rate behavior of tetracycline (TC) from a sustained‐release delivery system composed of an ethyl cellulose (EC) film and polyethyleneglycol (PEG) was studied using proton magnetic resonance (PMR) and UV spectroscopy. The optical density (OD) and...
10.1002/jps.2600770511.abs Human skin samples are permeable to adenosine delivered from 0.5–3% solutions in vehicles consisting of propionic acid, hexanoic acid, or mixtures of these in various ratios. The observed optimal Kp, hence flux, of adenosine from the binary vehicles is 0.4 × 10−3...
10.1002/jps.2600770510.abs The effect of methylcellulose on the particle size distribution and dosing accuracy of pre‐metered spray pump devices containing the peptide desmopressin (DDAVP) was investigated. Using gamma scintigraphy, the influence of methylcellulose on the in vivo deposition and...
10.1002/jps.2600770513.abs Nine azacycloalkanone (5‐, 6‐, or 7‐member ring) derivatives with an alkyl or alkenyl (terpene) chain (10, 15, or 20 carbons) were compared with 1‐dodecylazacycloheptan‐2‐one (azone, 1) for their effects on the percutaneous penetration of 6‐mercaptopurine...
10.1002/jps.2600770502.abs The pharmacokinetics of metoclopramide was studied in chronically instrumented pregnant and nonpregnant sheep. Metoclopramide was administered to the ewe by intravenous bolus injections (on a crossover basis) of 10, 20, and 40 mg, with an additional 80‐mg dose to the...
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