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10.1002/jps.2600770317.abs A novel method of measuring membrane‐water partitioning characteristics of very hydrophobic organic chemicals is described. Partition coefficients are reported for a series of halogenated aromatic hydrocarbons of varying molar volume between water and...
10.1002/jps.2600770316.abs The production of a known mammalian metabolite of the antihistamine triprolidine through fungal metabolic transformation has been demonstrated. The filamentous fungus Cunninghamelta elegans ATCC 9245 was grown in Sabouraud dextrose broth containing triprolidine...
10.1002/jps.2600770310.abs Heptakis(2,6‐di‐Oethyl)‐p‐cyclodextrin (2) was prepared and its physicochemical properties, such as aqueous solubility and surface activity, were compared with those of pcyclodextrin (1) and heptakis(2,6‐di‐Omethyl)‐cyclodextrin (3). A possible utility of...
10.1002/jps.2600770318.abs A specific and reproducible high‐performance liquid Chromatographic (HPLC) procedure was developed for the quantitative analysis of carboplatin (JM‐8) in dog plasma ultrafiltrate. Plasma ultrafiltrate samples were generated using Amicon Centrifree micropartition...
10.1002/jps.2600770315.abs Antisera of high sensitivity and selectivity were obtained from rabbits immunized with conjugates of hemisuccinylated fluphenazine and porcine thyroglobulin. The antiserum selected (titer 1:6000) for the development of the RIA was obtained after a priming dose and a...
10.1002/jps.2600770312.abs The colored powders produced by the adsorption of four adsorptiochromic spiropyrans to many solids (silica gel, silicic acid, fumed silica, alumina, microcrystalline cellulose, talc, titanium dioxide) were examined by diffuse reflectance spectroscopy. The reflectance...
10.1002/jps.2600770303.abs At therapeutic free concentrations (120‐360 nM in rheumatoid arthritis), the accumulation ratio for chloroquine (7‐chloro‐4‐((4‐(diethylamino)‐1‐methylbutyl)amino)‐quinoline; CQ) in viable isolated rat hepatocytes is 795 ± 33, which is of the same order...
10.1002/jps.2600770319.abs Nicotine in plasma can be determined by high‐performance liquid Chromatography with electrochemical detection to upper picogram levels. A simple one‐step extraction, which requires only 0.1 mL of plasma and is able to recover>85% of nicotine in plasma, is described....
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