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10.1002/jps.2600771211.abs ‘Zero‐crossing’ derivative spectrophotometry has been used for determining binary mixtures of dicloxacillin Na and ampicillin Na, which are penicillins with closely overlapping absorption spectra. The procedure is rapid, simple, nondestructive, and does not...
10.1002/jps.2600771206.abs Binding of antiarrhythmics to phospholipids has been quantified by measuring the drug‐induced fluorescence increase in 8‐anilino‐1‐napthalenesulfonate (ANS)‐treated phosphatidylcholine membranes. The ability of test compounds to increase fluorescence intensity...
10.1002/jps.2600771205.abs Experimental factors and determinants of the protein binding of enoximone (a new cardiotonic agent) were investigated in human serum from healthy, drug‐free subjects using a rapid ultrafiltration method; these factors and determinants included nonspecific binding to...
10.1002/jps.2600771212.abs Two pseudopolymorphic forms of oxyphenbutazone, a benzene solvate (Solvate B) and a cyclohexane solvate (Solvate C), were prepared by recrystallization from benzene and cyclohexane, respectively. The forms were characterized by means of differential scanning...
10.1002/jps.2600771203.abs A technique using gas chromatography–mass spectrometry and deuterated internal standards is described for the quantitation in brain tissue of four constituents of the intoxicating beverage kava. Dihydrokawain, kawain, desmethoxyyangonin, and yangonin were administered...
10.1002/jps.2600771214.abs Co‐product or co‐reactant data is commonly used to obtain the hydrolysis rate constants for two‐step consecutive pseudo‐first‐order reactions. Different methods to calculate the rate constants from experimental data were evaluated using data simulated with and...
10.1002/jps.2600771210.abs The influence of hydration on the dynamic properties of rat epidermal skin has been determined with the use of solid‐state NMR. Samples were prepared with varying degrees of hydration using deuterium oxide and then subjected to CP–MAS...
10.1002/jps.2600771208.abs The in vivo performance of hydralazine sustained‐release dosage forms prepared using an ethylcellulose‐coated drug:resin complex was studied in healthy males who were determined to be slow acetylators. Two studies were performed. The first study (I) compared four...
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