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10.1002/jps.2600750913.abs The relative bioavailability of metaproterenol (3, 5‐dihy‐droxy‐α‐((isopropylamino)methyl)benzyl alcohol) following a single dose (10‐mg metaproterenol sulfate tablet) was studied in six normal male volunteers using coadministration of a solution of a...
10.1002/jps.2600750914.abs The influence of food and water intake on mefenamic acid (N‐2, 3‐xylylanthranilic acid) bioavailability from commercial capsules of high bioavailability was studied in four healthy male volunteers. The drug was administered as a single oral dose of 250 mg, under...
10.1002/jps.2600750908.abs An in situ rat intestinal preparation was modified to include portal and jugular venous blood collection techniques as well as sampling from the intestinal lumen. Viability could be maintained for 3 h. The utility of the preparation was examined by studying the...
10.1002/jps.2600750915.abs Eighteen healthy adult volunteers completed an open‐label, four‐way crossover study designed to determine the bioequivalency of 160‐mg cibenzoline (2‐(2, 2‐diphenylcyclopropyl)‐4, 5‐dihydro‐1 H‐imid‐azole) capsules and tablets, their relative...
10.1002/jps.2600750918.abs The in vitro adsorption and coadsorption of acetaminophen and N‐acetylcysteine using simulated gastric (pH 1.2) and intestinal (pH 7.0) conditions were examined for a range of charcoal‐to‐drug ratios between 1 and 7. Although both substances were adsorbed by the...
10.1002/jps.2600750919.abs A relatively high complexation affinity has been found for coomassie blue G‐250 and the following amino acids: arginine; tyrosine; lysine; and histidine. A linear relationship was observed between log molar absorptivity and log molecular weight of 52 of 69 proteins,...
10.1002/jps.2600750902.abs In this paper we describe the synthesis and characterization of magnetic microcapsules, intended for use in vivo, and which contain polyethyleneimine nucleophilic targets capable of trapping electrophilic carcinogens. The microcapsules, 15–50 μm in diameter, consist...
10.1002/jps.2600750903.abs A method for the determination of the amount of insulin in a vesicle formulation was developed. Samples were treated with anion exchange resin to quantitatively remove the insulin outside the vesicle walls. Encapsulated insulin was released from vesicles by disruption...
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