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10.1002/jps.2600740804.abs Morphine 3‐sulfate, which carries a polar, acidic group at the 3‐position much like morphine, does not differ greatly in analgesic potency from morphine following intracerebroventricular administration. This differs from the non‐ionizable 3‐methyl and 3‐ethyl...
10.1002/jps.2600740816.abs Experiments have been undertaken to examine the validity of the method of Ammon and Walter for the determination of bile acid monomer concentrations in taurocholate—lecithin (TC—L) solutions. The procedure involves, basically, the uptake of the bile acid monomer by...
10.1002/jps.2600740802.abs Octanol‐water partition coefficents of 102 aliphatic, polychloro aliphatic, and aromatic non‐hydrogen‐bond donor and hydrogen‐bond donor solutes are well correlated (4 = 0.989, DS = 0.175) by the equalion: logKow = 0.20 + 2.74 V/100 − 0.92π* − 3.49β, where...
10.1002/jps.2600740806.abs With the aid of the computer, ∼8000 compounds that incorporate a carbamate or thiocarbamate moiety, which have been tested as potential anticancer agents at the National Cancer Institute (NCI), were classified and their structure–activity correlations against the in...
10.1002/jps.2600740819.abs Coralyne analogues, isomers, and related alkaloids were examined as inhibitors of reverse transcriptase of RNA tumor viruses in the presence of polyriboadenylic acid–oligodeoxythymidylic acid (Poly rA.oligo dT), polydeoxyadenylic acid–oligodeoxythymidylic acid (Poly...
10.1002/jps.2600740807.abs Drug–serum protein binding was evaluated in genetically obese Zucker rats, their lean littermates, and lean Sprague–Dawley rats. The free fraction (fp) of phenytoin was significantly higher in the obese rat (fp = 0.177) compared to its lean littermate (fp = 0.136),...
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