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10.1002/jps.2600740604.abs The urinary protein binding, kinetics, and dynamics of furosemide were studied in five nephrotic patients after intravenous dosing. Serial plasma and urine samples containing furosemide were analyzed by HPLC, and drug binding to plasma and urinary proteins was...
10.1002/jps.2600740611.abs In nonpolar solvents a solute may self‐associate through polar interactions, exposing its nonpolar surface to a solvent with a low solubility parameter, δ1. In polar solvents a solute in solvated, presumably, by the polar groups of the solvent. This...
10.1002/jps.2600740610.abs There is a need to identify suitable blends of solvents to dissolve drugs. Empirical approaches, such as trial‐and‐error and response surface, require several solubility measurements. In this study the UNIFAC method was used to predict solubility in highly nonideal...
10.1002/jps.2600740608.abs These studies were undertaken to test the hypothesis that interfacial resistance may be an important rate‐limiting factor in cholesterol gallstone dissoluton. The addition of lincomycin hydrochloride to the gallbladder bile of dogs in an in vitro bath system resulted...
10.1002/jps.2600740626.abs A stability‐indicating reversed‐phase high‐performance liquid chromatographic method using a refractive index detector is described for the determination of propylene carbonate in pharmaceutical formulations. Good precision and accuracy of the method was...
10.1002/jps.2600740625.abs In this study, three techniques for measuring the free fractions of phenobarbital and phenytoin were compared: equilibrium dialysis, ultrafiltration, and the Hummel and Dreyer method for gel permeation chromatography. In their therapeutic range (15–40 and 10–20...
10.1002/jps.2600740605.abs The effect of rate of perfusion, volume, pH of the perfusate, and partition coefficient of the drug on the rate of in situ nasal absorption in rats was examined. The studies showed that the rate constant for the nasal absorption of phenobarbital was independent of the...
10.1002/jps.2600740616.abs The interaction between caffeine and hydroxylic derivatives (phenols, water) has been studied by infrared (IR) spectroscopy in 1,2‐dichloroethane. The formation constants, enthalpies, and entropies of complex formation have been determined. The IR spectra in the νOH...
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