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10.1002/jps.2600740306.abs A series of analogues related to helenalin demonstrated moderate capability for inhibiting the growth of murine P‐388 lymphocytic leukemia cells in vivo and in vitro. The growth inhibition correlated with suppression of both DNA and protein synthesis in P‐388 cells....
10.1002/jps.2600740330.abs The synthesis and some of the spectral properties of N2‐((S)‐1‐carboxy‐3‐phenylpropyl)‐L‐lysyl‐L‐proline (lisinopril, MK‐521) are described. This compound inhibits angiotensin‐converting enzyme with an IC50 of 1.2 × 10−9 M.
10.1002/jps.2600740327.abs Simple coacervation of bovine serum albumin was studied to prepare biodegradable microcapsules. Three types of microcapsules, which differed in shape, were obtained by changing either core size or the bovine serum albumin concentrations of the coacervating systems....
10.1002/jps.2600740304.abs New dihydropyridine pyridinium salt‐type redox carrier systems were developed in which the drug is linked via the ring nitrogen atom of nicotinamide. The rate of oxidation of the dihydropyridine forms, and thus the overall and brain‐specific distribution of the...
10.1002/jps.2600740310.abs Thioamide, 1, is shown to exist as two rotameric forms in solution, rotamer A and B. Conformations of the rotamers are defined to be trans for rotamer A and cis for rotamer B. Energy barriers restricting rotation about the CN bond of the thioamide group are examined...
10.1002/jps.2600740315.abs An enzyme immunoassay for the direct measurement of elcatonin, a synthetic analogue of eel calcitonin with hypocalcemic activity, in rat and dog plasma was developed. Elcatonin was conjugated to β‐galactosidase using an N‐succinimidyl ester, and the product was...
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