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10.1002/jps.2600741203.abs The phase behavior of two series of phosphatidylcholines (PC) possessing carbamyloxy‐linked fatty acids has been studied by differential scanning calorimetry. These non‐natural phosphatidylcholines are of interest because they possess the capability of forming...
10.1002/jps.2600741206.abs An analytical method is described for the concurrent determination of dihydralazine (1) and hydralazine (2) in human plasma as unchanged or apparent compounds. For the assay of the unchanged compounds, plasma samples were acidified with 0.02 M HCI and derivatized first...
10.1002/jps.2600741210.abs The nasal absorption of L‐tyrosine and the effect of structural modification on that absorption have been studied using an insitu experimental technique. The extent of nasal absorption of the amino acid was found to be the same at pH values of 4.0 and 7.4 but...
10.1002/jps.2600741202.abs In order to understand the redox properties of diaziquone (AZQ) and the reductive alkylation role of its one‐electron reduced free radical anion AZQ− in biological systems, we investigated the electrochemical and structural properties of AZQ and its reduced species...
10.1002/jps.2600741204.abs The ability of plasma lipoproteins to act as carriers in sitespecific drug delivery systems was evaluated by determining the disposition and pharmacological effects of β‐sitosteryl‐β‐D‐glucopyranoside (SG, 3). In the disposition studies, (3H)SG was absorbed...
10.1002/jps.2600741211.abs Several acyclic puromycin analogues containing hydrocarbon substituents on the 1′‐position of the aminoethoxymethyl moiety were synthesized and tested for antiviral activity. The N‐carbobenzoxy intermediate 7c was active in vitro against Mengo and Semliki Forest...
10.1002/jps.2600741212.abs The dissolution behavior of three carboxylic acids of variable aqueous solubility but with approximately equal pKa values into aqueous buffered solutions has been studied as a function of pH and of buffer properties. The dissolution from constant‐surface‐area...
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