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10.1002/jps.2600720805.abs Eight nonionic surface‐active agents were each incorporated at a concentration of 10% into a white petrolatum ointment base containing 10% flufenamic acid with or without dimethyl sulfoxide. Percutaneous absorption was studied by determining the plasma concentration...
10.1002/jps.2600720834.abs A rapid and sensitive high‐performance liquid chromatographic (HPLC) assay for the quantitative determination of doxylamine in plasma is described. The drug levels of doxylamine in plasma were monitored after the oral administration of a single 25‐mg tablet of...
10.1002/jps.2600720821.abs An investigation of the USP assay of chlorthalidone tablets showed that variable degradation of chlorthalidone occurred during assay preparation. The degradation products were isolated and identified. A stability‐indicating high‐performance liquid chromatographic...
10.1002/jps.2600720835.abs A rapid, precise, sensitive, and specific assay for nitroglycerin in sublingual, sustained‐release, and ointment dosage forms using high‐performance liquid chromatography is described. The nitroglycerin dosage forms were dissolved in methanol, filtered, and injected...
10.1002/jps.2600720829.abs A GLC procedure has been developed for the determination of hydrazine in hydralazine and isoniazid drug raw materials, single and multicomponent tablets, injectables, and syrups. The method is based on the derivatization of hydrazine with benzaldehyde to form...
10.1002/jps.2600720803.abs Phthalimide analogues have been shown to effectively lower serum cholesterol and triglyceride levels in rats and mice. The mode of action of these agents was not to suppress the appetite of animals, but rather to reduce the activities of key enzymes in the early...
10.1002/jps.2600720806.abs A steady‐state approach is proposed to examine the contribution that the lung makes to the total body elimination of medium‐to high‐clearance drugs. Carbamazepine, a potential candidate of pulmonary metabolism, was investigated by infusion into the femoral vein in...
10.1002/jps.2600720833.abs A high‐performance liquid chromatographic method is described for the simultaneous determinations of cefsulodin and cefotiam in serum and bone marrow blood samples. After extraction with acetonitrile, the cephalosporins were applied to a reverse‐phase column with an...
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