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10.1002/jps.2600720629.abs A spectrophotometric method was developed for determining promethazine hydrochloride (I) complexed with bromcresol green and then extracted with chloroform. The complex in chloroform showed maximum absorption at 415 nm and obeyed Beer's law over 1.2–8.5 μg/ml. The...
10.1002/jps.2600720622.abs 3‐Fluoro‐, 3‐chloro‐, and 3‐bromocyclophosphamide were prepared from the reaction of trifluoromethylhypofluorite, sodium hypochlorite, and bromine with the anticancer drug cyclophosphamide. Treatment of cis‐ and trans‐4‐phenylcyclophosphamide and...
10.1002/jps.2600720616.abs The antitumor effect of immobilized L‐asparaginase was tested against lymphoid leukemia in mice with concomitant scanning of the L‐asparagine level in serum. L‐Asparaginase was immobilized in microspheres of polyacrylamide or polyacryldextran. These particles were...
10.1002/jps.2600720607.abs The response patterns of the time profile of plasma drug level to dose elevation after subcutaneous administration of a practically water‐insoluble drug in aqueous suspension were investigated. Equations to predict the plasma drug concentration at any time and the...
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