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10.1002/jps.2600710614.abs The sweet compounds 2‐methyl‐ and 3‐methylcyclohexyl‐and 2‐cyclohexenylsulfamates were fed to Wistar albino rats. The urine (and feces in the case of 2‐cyclohexenylsulfamate) was examined for possible amine, ketone, and alcohol metabolites. The total percent...
10.1002/jps.2600710623.abs Following oral dosing to steady state, the disposition of S(—)‐and R(+)‐propranolol and their corresponding glucuronide conjugates was studied in 4 healthy adults using doses from 40 to 320 mg/day of the racemate. Steady‐state plasma concentrations of...
10.1002/jps.2600710611.abs The theoretical basis for using dipole moment as a free‐energy related parameter in studying drug‐receptor interaction and quantitative structure‐activity relationship (QSAR) is presented. Over 300 group dipole moments for aromatic substituents were compiled using...
10.1002/jps.2600710625.abs The axial and radial tensile strengths were compared to the hardness of compressed tablets containing various concentrations of lubricants. Since radial tensile strength measurement considers the thickness of a tablet, and only tensile stress and axial tensile strength...
10.1002/jps.2600710628.abs A method is described to measure the in vitro metabolism of theophylline by liver microsomes. The formation of 1‐methyluric acid and 1, 3‐dimethyluric acid in incubation mixtures was determined by high‐performance liquid chromatography. The formation of both...
10.1002/jps.2600710608.abs The pectin‐gelatin complex coacervate system was evaluated and characterized. The effects of final pH, mixing pH, colloid ratio, and solution concentration were investigated. A recovery procedure yielding microglobules of a controlled and uniform size in dry powder...
10.1002/jps.2600710607.abs A GLC‐nitrogen phosphorous detector (NPD) method for the quantitative determination of trifluoperazine in plasma is described. It depends on an organic extraction of trifluoperazine and the internal standard prochlorperazine from basified plasma. Following the...
10.1002/jps.2600710604.abs Octanol‐water partition values were calculated using fragmentation values and measured rapidly by high‐pressure liquid chro‐matography (HPLC) on bonded octadecylsilane supports. Log P for in‐dolizine, π, and fragment (f) values for the indolizinyl substituents...
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