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10.1002/jps.2600710421.abs The partition coefficient between tissue and blood used in physiologically‐based pharmacokinetic modeling analysis was investigated using the concept of clearance. New equations were derived and compared with previously reported equations in constant intravenous...
10.1002/jps.2600710426.abs A series of 1,4‐bis(4‐guanylphenylethyl)benzenes, including masked amidines in which the guanyl function is incorporated into a heterocyclic ring, were prepared for screening as potential antitrypano‐somal agents. Some of these compounds were active against...
10.1002/jps.2600710409.abs To develop a parenteral solution of relatively water‐insoluble metronidazole (2‐methyl‐5‐nitro‐1H‐imidazole‐1‐ethanol), its phosphate ester was synthesized via two routes. One route utilized 2‐cyanoethyl phosphate and the other utilized pyrophosphoryl...
10.1002/jps.2600710408.abs Data are presented showing that the anomalous dissolution behavior of ticrynafen in simulated intestinal fluid without enzyme is due to the presence of potassium ions in the dissolution medium. Solubility studies indicate that an insoluble 1:1 complex is formed between...
10.1002/jps.2600710419.abs The physical alignment of the paddle and the vessel is critical in obtaining reproducible results from the USP dissolution test with Apparatus 2. Large variations in dissolution results were traced to minor variations in alignment of different apparatuses.
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