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10.1002/jps.2600710312.abs Five triorganotin 5‐nitro‐2‐furoates were synthesized by reacting 5‐nitro‐2‐furoic acid with either the corresponding bis(triorganotin) oxide or the corresponding triorganotin hydroxide. The IR spectrum of each compound was obtained over the...
10.1002/jps.2600710303.abs The blood level pharmacokinetics of model nonmetabolizable and nonprotein bound anionic compounds (pKa 3.3–3.4), namely, benzoylformic acid (I), D‐(−)‐mandelic acid (II), and p‐methyl benzoylformic acid (III), which are excreted in the urine in the unchanged...
10.1002/jps.2600710313.abs The validity of a radioimmunoassay (RIA) for research on the pharmacokinetics of morphine has been questioned because of the possible measurement of cross‐reactive metabolites. An RIA using antiserum derived from the 3‐O‐carboxymethylmorphine hapten was compared...
10.1002/jps.2600710315.abs An aqueous solution of trimedoxime bromide, atropine, and benactyzine hydrochloride was formulated to have maximum stability as an antidote in organophosphorus poisoning. The stability of the mixture in glass and plastic cartridges was determined. Glass cartridges were...
10.1002/jps.2600710311.abs A series of 15 amidine, iminopiperidine, iso(thio)urea, and guanidine derivatives and six 2,5‐dihydro‐1,3,5,2‐triazaphosphorines were synthesized. Most of the compounds were tested for ability to react with L‐cysteine and for antitumor activity against sarcoma...
10.1002/jps.2600710320.abs A series of new bisbrusatolyl and brusatolyl esters and related compounds were synthesized and tested for in vivo antileukemic activity against a quassinoid sensitive strain of P‐388 lymphocytic leukemia in BDF1 mice. The bisbrusatolyl malonate, succinate, glutarate,...
10.1002/jps.2600710327.abs A new quantitative GLC method for analysis of lidamidine hydrochloride (1) was developed. The method was based on derivatization of 1 to 1‐(2,6‐dimethylphenyl)‐4‐methylamino‐dihydro‐1,3,5‐triazin‐2‐one (II) using dimethylformamide dimethylacetal...
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