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10.1002/jps.2600661026.abs The fetal rat heart in organ culture was used to investigate rate changes by various cardioactive agents. Concomitantly, the effect of these pharmacologically induced rate changes on steady‐state cyclic adenosine monophosphate levels was determined. Isoproterenol...
10.1002/jps.2600661019.abs The apparent first‐order generation rate constant, kapp, of Escherichia coli is a function of fluorouracil concentration, C, i.e., 1/(k0–kapp) = κ1(1/C) +κ2 where k0 is the constant in the absence of drug. A routine procedure, using only six counts to establish a...
10.1002/jps.2600661047.abs An organoboron carboxamido derivative of tetracycline, designed for use in the 510B‐thermal neutron‐capture treatment of cancer, was synthesized under the conditions of the Mannich reaction using perhydro‐2‐phenyl‐1,3,6,2‐dioxazaborocine as the amine...
10.1002/jps.2600661046.abs A rapid, specific, and precise spectrophotometric assay for the determination of pyridoxal phosphate is described. The assay allows for the determination of the cofactor between 0.1 and 1.0 μg/ml. Its applicability to pyridoxal phosphate in biological fluids was...
10.1002/jps.2600661015.abs The effect of binder solution viscosity and drying temperature on the intergranular migration of propoxyphene hydrochloride was studied. Wet granulations containing the drug were prepared using binder solutions with viscosities ranging from 1 to 1000 cps. Temperature...
10.1002/jps.2600661021.abs The antisecretory (determined from salivary flow rates) and antimotility (determined from riboflavin absorption) effects of usually recommended doses of propantheline, hexocyclium, and isopropamide were compared in four adult volunteers. Both propantheline and...
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