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10.1002/jps.2600651121.abs Blood from two male and two female donors was exposed at 37° for 4 hr to concentrations of 60.0, 6.0, 0.6, and 0.06 μg of a widely used plasticizer, bis(2‐ethylhexyl) phthalate, per milliliter of blood. The bis(2‐ethylhexyl) phthalate was solubilized with...
10.1002/jps.2600651109.abs The time variation of changes in the chlorpromazine‐induced pupil diameter decrease was studied following varying bolus and slowly infused intravenous doses administered to rabbits. The observed pharmacological response data were converted, via the use of a...
10.1002/jps.2600651138.abs Molecular orbital calculations were used to investigate the antischistosomal agent, niridazole, and an inactive derivative, 1‐(5‐nitro‐2‐thiazolyl)‐2‐ethylurea. The CNDO/2 calculations revealed that the inactive derivative had a preferred conformation...
10.1002/jps.2600651130.abs A rapid stability‐indicating GLC method is described for the determination of fenclorac as the diethylamine salt in dosage formulations. The procedure is also applied in detecting and quantitating the weight percent of 3‐chloro‐4‐cyclohexylphenylglycolic acid...
10.1002/jps.2600651125.abs Trifluoperazine and pericyazine were formulated using both the hydrochloride and embonate salts, and some comparisons were made with the activity of fluphenazine salt and ester formulations. Simple solutions in polyethylene glycol, gelled aqueous solutions, nonaqueous...
10.1002/jps.2600651123.abs Changes in tear film pH were observed during the 1st hr after instillation of pilocarpine in various dosage forms to the rabbit eye. In anesthetized rabbits, with periodic blinking induced electrically, commercial formulations of pilocarpine salts applied as drops or a...
10.1002/jps.2600651105.abs The absorption of unbranched aliphatic alcohols in the rabbit vagina was studied using a perfusion method, and the absorption rates were found to be first order with respect to the drug concentration in the vagina from methanol to octanol. A physical model involving an...
10.1002/jps.2600651135.abs The quantitative determination of morphine in paregoric by reversed‐phase high‐pressure liquid chromatography is described. The method is simple, accurate, and fast compared to the USP method. Benzoic acid in paregoric also can be determined quantitatively with the...
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