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10.1002/jps.2600610623.abs A rapid GLC procedure for the precise estimation of salicylic acid in codeine‐ and propoxyphene‐type capsule and tablet analgesic formulations is presented. The sample material is treated with diazomethane prepared in tetrahydrofuran solution, and the salicylic acid...
10.1002/jps.2600610620.abs Experiments directed toward investigating the verity of an electrometric method, which is applicable to the determination of the net density of fixed charge residing on in vitro and in vivo tissue surfaces, were performed. The fixed sulfonate‐anion charge capacity of...
10.1002/jps.2600610614.abs Blood levels of sulfamethizole in dogs following the administration of timed‐release tablets are reported. Tablet formulations containing 5% glyceryl monostearate were employed for in vivo studies because the in vitro release from this formulation extended more than...
10.1002/jps.2600610615.abs Effects of the nonsystemic antacid aluminum hydroxide gel, the adsorbent kaolin, and the systemic antacid sodium bicarbonate were tested on the absorption of the basic drug pseudoephedrine hydrochloride, administered in tablet form to six young adult males. The...
10.1002/jps.2600610633.abs A method for the dehistaminization of organ extracts was studied using ion‐exchange column chromatography. Resin A, a methacrylic polymer, was found to be the most efficacious resin used in the study. However, Resin C, another methacrylic polymer, gave a high yield...
10.1002/jps.2600610630.abs A relationship between drug distribution and elimination in multicompartment systems has been demonstrated, which suggests that under certain conditions a decrease in the elimination rate constant (ket) results in a significant decrease in the apparent volume of...
10.1002/jps.2600610624.abs A method based on TLC separation and subsequent colorimetric determination was developed for the determination of p‐hydroxyphenoxyacetic acid in phenoxymethyl penicillin (penicillin V) fermentation samples. The p‐hydroxyphenoxyacetic acid is extracted from...
10.1002/jps.2600610603.abs The effect of alkyl chain length on the physicochemical properties of a series of p‐aminobenzoate esters, determinant of the rate at which they penetrate inert barriers, was investigated. Relationships are drawn for the influence of chain length on partition...
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