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10.1002/jps.2600581118.abs A study was made of the mechanism of hemolysis by cationic surface‐active agents. Phospholipids were found to be released from the cell membrane prior to lysis by the cationic agents under the conditions of physiological pH and ionic strength, indicating an important...
10.1002/jps.2600581110.abs Activated charcoal, Arizona montmorillonite, and evaporated milk were compared for their ability to reduce gastrointestinal absorption of three potential poisons. Time‐course drug‐concentration studies were performed on kerosene‐ and aspirin‐treated animals....
10.1002/jps.2600581115.abs The influence of a nonionic surfactant and certain physiologic surfactants and components of gastric juice on the dissolution rate of drug powders was examined. In addition, the effects of pre‐micellar concentrations of surfactant on the dissolution rate of aspirin...
10.1002/jps.2600581114.abs Nitrofurantoin, a urinary tract antibacterial, was administered daily in different dosage forms to dogs using a multiple‐dose regimen and the urinary drug excretion determined. Results are presented which show that two oral dosage forms, microcrystalline drug in a...
10.1002/jps.2600581122.abs The colorimetric method for the estimation of phenols which is based on oxidative condensation with 4‐aminoantipyrine (4‐AAP) yielded erroneous results when performed in the presence of nonionic surfactants and related materials. For example, solutions of...
10.1002/jps.2600581121.abs A series of linear acyl and alkoxy esters at Position 7 in the lincomycin molecule were synthesized. None of the esters possessed protective properties comparable to those of lincomycin when given orally to experimentally infected mice.
10.1002/jps.2600581126.abs A study of the stem wood of Suriana maritima L. (Simarubaceae) has indicated the presence of a high molecular weight alkane fraction, β‐sitosterol, and a soluble form of lignin, a Brauns' native lignin. No previously reported investigation of this species has been...
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