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10.1002/jps.2600560720.abs Provisional, unofficial monographs are developed by the Drug Standards Laboratory, in cooperation with the manufacturers of the drug concerned, for publication in the Journal of Pharmaceutical Sciences. The ready availability of this information affords discriminating...
10.1002/jps.2600560721.abs A commercial single‐punch tablet machine (Manesty E 2) fitted with 1/2‐in. punches was instrumented with strain gauges to monitor the forces simultaneously on the upper punch and the die‐wall. The complete pressure cycles of a number of pharmaceutical materials at...
10.1002/jps.2600560716.abs D‐ and L‐Erythrose and D‐ and L‐threose were individually converted to their triacetates which were condensed with chloromercuri‐6‐benzamidopurine in the presence of titanium tetrachloride. After deacylation, the four crude mixtures of anomeric nucleosides...
10.1002/jps.2600560714.abs 5‐Methyl‐3 (2H)‐furanone (VIII) is produced from 2‐deoxy‐D‐ribose (I) under defined conditions of acid, temperature, and time, Its production is a direct function of sugar concentration and its ultraviolet absorbance serves as a sensitive assay for the...
10.1002/jps.2600560722.abs The metabolizing activity of the hepatic tissues in an isolated in situ liver preparation has been examined. In this experiment the organ remained connected to the other parts of the body, but its blood circulation was supplied by a pump‐oxygenator system. By this...
10.1002/jps.2600560734.abs Trichloroethyl carbonate was prepared from trichloroethanol and phosgene. It is a tasteless, crystalline solid with limited solubility in water. Pharmacological comparisons of trichloroethyl carbonate and trichloroethanol reveal that these compounds are about equitpxic...
10.1002/jps.2600560717.abs The relative binding to dihydrofolic reductase by 16 m‐substituted 4,6‐diamino‐1,2‐dihydro‐2,2‐dimethyl‐1‐phenyl‐s‐triazines—nine of which are newly synthesized— has been measured. Strong evidence is presented to indicate that the increased...
10.1002/jps.2600560737.abs Bis‐quaternary salts of 2, 4‐bis(dialkylaminoalkoxy)quinazolines were prepared from the corresponding bis‐tertiary amines as potential curaremimetic agents.
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