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10.1002/jps.2600530424.abs A group of compounds prepared from nopol has been synthesized for pharmacological evaluation. Preliminary studies indicate that they have only a very limited potential in this area, but further studies are in process.
10.1002/jps.2600530411.abs A procedure has been developed for the systematic evaluation of mechanical, thermal, and stability properties of polymeric materials through the study of unsupported films. Films of selected vinyl, acrylic, and cellulosic polymers were prepared by the knife edge...
10.1002/jps.2600530428.abs The relationship that exists between the discoloration of spray‐processed lactose and the presence of 5‐(hydroxymethyl)‐2‐furaldehyde (HMF) was investigated. The HMF was determined by reaction with 2‐thiobarbituric acid using procedures developed by Keeney and...
10.1002/jps.2600530409.abs The bi‐weekly, intraperitoneal administration of sodium cobaltinitrite in doses of 50, 60, and 70 mg./Kg. in mice subjected to the MCD50 of methylcholanthrene resulted in a reduction of tumor incidence to 31, 31, and 25 per cent, respectively, compared to 47 per cent...
10.1002/jps.2600530431.abs Prolonged administration of glycyrrhetinic acid was studied in immature female rats, castrated male donor parabionts, and mature cyclic rats. Glycyrrhetinic acid treatment for 7 days interfered with the uterotrophic response of immature rats to estradiol benzoate but...
10.1002/jps.2600530430.abs Thiamine hydrochloride was determined quantitatively by inverse isotope dilution in the presence of ascorbic acid, riboflavin, and nicotinic acid. The results obtained, using 100‐mg. quantities, indicated an average error of 0.1. per cent and a reproducibility of 0.27...
10.1002/jps.2600530425.abs A series of eight alkyl amino alkanol esters of p‐ethoxy benzoic acid were prepared having hydrogen, methyl, ethyl, isopropyl, butyl, t‐butyl, benzyl, and benzylmethyl groups so attached to give a secondary nitrogen in five of the compounds. Some physical properties...
10.1002/jps.2600530427.abs Gastrointestinal absorption of various spironolactone preparations was investigated in acute tests with dogs treated with an aldosterone‐like steroid. Absorption was determined by the appearance in plasma of aldadiene, a major spironolactone metabolite with...
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