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Purpose. To describe a case of 6-mercaptopurine acute fulminate hepatotoxicity. Case Summary. A 65-year-old male with adult acute lymphocytic leukemia was receiving mainte nance therapy with 6-mercaptopurine and methotrex ate when he presented with jaundice, nausea, diar rhea, dysuria, right...
Objective. To report the successful use of EMLA cream (a topical anesthetic) for the relief of neuro pathic pain in a patient with a liposarcoma. Case Summary. A 63-year-old male with a lipo sarcoma was admitted to the hospital to establish an effective pain control regimen. Despite the use of...
Purpose. The primary objective of this article is to discuss the pharmacology, pharmacokinetics, clinical use, and adverse effects of the approved topoisomer ase I inhibitors. This is the second in a series of two articles and will focus on irinotecan. Data Sources. We reviewed the literature...
The first European conference on the economics of cancer was held in Brussels, Belgium on November 19-21, 1997. This international meeting was organized under the European Organization for Research and Treat ment of Cancer. Approximately 300 participants from around the world, including...
Objective. The cellular functions of p53, the conse quences of the loss of p53 function, and the potential impact of p53 in oncology are reviewed within the framework of an overview of the molecular basis of cancer and cell cycle control. Data Sources. A MEDLINE search of articles from 1976 to...
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