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Azithromycin was orally administered to Dutch-belted rabbits following extracapsular lens extraction in one eye. At various times the animals were sacrificed, and serum and ocular tissues were obtained for drug level determination by HPLC-EC. Following a single dose, peak levels of drug in ocular...
The antihistaminic agent, emedastine, was tested for its ability to compete for 3 Hpyrilamine, 3 Htiotidine and 3 HN-methyl histamine binding to rodent brain H 1 , H 2 and H 3 histamine receptors, respectively. Emedastine exhibited the highest affinity for H 1 -receptors (dissociation constant, K...
Emedastine 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimidazole difumarate was evaluated for topical ocular anti-histaminic activity in histamine and antigen stimulated conjunctivitis models. Concentration-dependent inhibition of histamine induced vascular permeability changes occurring...
Carnitine plays an important role in the metabolism of fatty acids. Its presence is considerable in tissues that use fatty acids as an important source of energy, such as the heart and skeletal muscle. Free carnitine and acid soluble acylcamitines are present in various tissues of the rabbit eye....