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DNA polymerases with intrinsic proofreading activity interact with DNA primer/templates in two distinct modes, corresponding to the complexes formed during the 5′–3′ polymerization or 3′–5′ editing of a nascent DNA chain. Thermodynamic measurements designed to quantify the energetic...
The transcription factors C/EBPα and Sp1 functionally interact to induce expression of specific genes during myeloid and epithelial cell differentiation. The C/EBPα-Sp1 transcription factor “module” binds to enhancer elements within the upstream regulatory sequences of target genes. In our...
Diseases such as type 2 diabetes, Alzheimer's and Parkinson's are associated with the formation of amyloid. The transmissible spongiform encephalopathies, such as variant Creutzfeldt-Jakob disease, are believed to result from infectious forms of amyloid proteins termed prions. The ability of...
Leu100Ile, Val106Ala and Val108Ile are mutations in HIV-1 reverse transcriptase (RT) that are observed in the clinic and give rise to resistance to certain non-nucleoside inhibitors (NNRTIs) including the first-generation drug nevirapine. In order to investigate structural mechanisms of...
Domains are the evolutionary units that comprise proteins, and most proteins are built from more than one domain. Domains can be shuffled by recombination to create proteins with new arrangements of domains. Using structural domain assignments, we examined the combinations of domains in the...
Physiological media constitutes a crowded environment that serves as the field of action for protein–protein interaction in vivo . Measuring protein–protein interaction in crowded solutions can mimic this environment. In this work we follow the process of protein–protein association and its...
Helix–helix interactions, such as those that occur in coiled-coil domains, four-helix bundles, or membrane-spanning helical bundles, are important to the structural organization and function of numerous proteins. However, tractable peptide models for studying such structural elements have been...
We have studied the physical properties of a segment of condensed chromatin that lies upstream of the chicken β-globin locus. This segment can be excised from an avian erythroleukemia cell line by restriction enzyme digestion and released from the nucleus as an essentially homogeneous fragment...
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