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The majority of commonly used liposomes are supposed to enter cells through an endocytotic pathway and to be delivered to the lysosomes where enzymatic degradation of the lipids and the encapsulated material can occur. Therefore liposomes that do not end up in the lysosomes have been designed....
A procedure is reported for the high-yield entrapment of a wide variety of solutes in small liposomes. The procedure entails mixing of preformed “empty” (water-filled) small unilamellar vesicles (SLFV) (60-80 nm diameter) with sucrose and the solute destined for entrapment. Using appropriate...
Over the past years we have designed and synthesized a new class of synthetic vectors called phosphonolipids and then shown their ability to transfect lungs cells of mice with efficiency. One of them, GLB73, gave high levels of transfection. In the study reported here, we explored the potential...
In this study, tumor uptake and clearance of doxorubicin were determined for two formulations of the drug: the free form in aqueous solution and the encapsulated form in polyethylene glycol-coated (pegylated, STEALTH®) liposomes composed of cholesterol/hydrogenated soy phosphatidylcholine/...
Cationic lipid-containing nonviral vectors for intracellular DNA delivery (lipoplexes) are becoming an important tool in a number of applications in life sciences, biotechnology, agriculture, and medicine. They became a biotechnology industry product on their own, being marketed as transfection...
The present study describes a new phase-specific assay system for the detection of anti-phospholipid antibodies, based on the finding by 3I P NMR analysis that phospholipid can be quantitatively retained on nitrocellulose paper in a phase-sensitive fashion. Using this system, we demonstrate that...
Doxorubicin loads quite efficiently into preformed citrate containing liposomes (<200 nm) in response to an inside-acidic pH gradient: >95% loading for drug/lipid as high as 1:1 w/w. In fact, doxorubicin's loading was found to exceed theoretical predictions because it forms an insoluble complex...
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