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Cationic liposomes are a useful in vitro but as yet unproven in vivo delivery system for oligonucleotides. An understanding of the mechanism of delivery mediated by cationic lipid/oligonucleotide complexes has been lacking. In this review, we describe recent results concerning several steps of...
Mycobacterium avium (M. avium) can survive within macrophages, and alters various functions of its cellular host. Liposomes and other particulate drug carriers have been investigated as a means for enhancing drug delivery to the intracellular site of infection via the endocytic pathway. We have...
Much attention has focused on cationic liposomes for delivery of antisense oligonucleotides. While these reagents demonstrate efficient delivery and potentiation of antisense oligonucleotides in vitro under serum-free conditions, then-use in vivo may be limited. This report highlights issues...
A targeted vector allowing enhanced gene transfer to human hepatocellular carcinoma (HCC 1 ) cells in vitro was developed using cationic liposomes covalently conjugated with the mAb AF-20. This high affinity antibody recognizes a rapidly internalized 180 kDa cell surface glycoprotein which is...
This study reports the formulation and preliminary clinical testing of liposomes as a topical drug delivery system for interferon a (IFN α) in the treatment of genital human papillomavirus (HPV) infections. Intron A (IFN α-2b) was encapsulated into multilamellar liposomes, composed of soya...
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