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Recombinant interferon- β (IFN- β ) protein is used successfully for the treatment of multiple sclerosis (MS). Gene therapy might be an alternative approach to overcome drawbacks occurring with IFN- β protein therapy. A critical issue in developing a new approach is detection of biologically...
Cytokines play critical roles during T cell development; however, it is unclear to what extent development is altered by the high levels of cytokines produced during immune responses. A potential mechanism to shield developing cells from cytokine influence is attenuation of cytokine signaling....
In experimental settings, the increased intestinal permeability (IP) following severe trauma is associated with increased serum concentrations of cytokines. Multiply injured patients are susceptible to the development of multiple organ failure (MOF). The aim of this study was to determine if...
Coupled bone turnover is directed by the expression of receptor-activated NF-κB ligand (RANKL) and its decoy receptor, osteoprotegerin (OPG). Proinflammatory cytokines, such as interleukin-1 β (IL-1 β ) and tumor necrosis factor- α (TNF- α ) induce RANKL expression in bone marrow stromal...
The proinflammatory cytokine, interleukin-18 (IL-18), is a natural killer (NK) cell activator that induces NK cell cytotoxicity and interferon- γ (IFN- γ ) expression. In this report, we define a novel role for IL-18 as an NK cell protective agent. Specifically, IL-18 prevents NK cell death...
The immunomodulatory efficacy of interferon- γ (IFN- γ )-associated cytokines coadministered with a plasmid DNA vaccine has been investigated, with variable results. Therefore, to test the immunomodulatory effect of IFN- γ -associated cytokines as vaccine adjuvant, the present study evaluated...
This work aimed to show that an important, yet unrecognized, role of KC chemokine in the liver is regulation of gene expression. KC expression in the liver stimulated three classes of genes in this temporal order: immediate-early genes, proinflammatory genes, and profibrotic genes. Transcription...
Because the induction of interleukin-1 β (IL-1 β ) is critical to antibacterial host defenses and its excessive generation is a prominent component of sepsis, regulation of this proinflammatory cytokine is a critical factor in the immune response to lipopolysaccharide (LPS). We previously...
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