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Interferon- β (IFN- β ) is biologically unstable under physiologic conditions in vitro and is cleared rapidly from the bloodstream on administration in vivo . In the present study, we demonstrate that a soluble recombinant form of the type I IFN receptor subunit, sIFNAR-2, can neutralize the...
To test the hypothesis that HIV infection brings about an alteration in the immune response to tuberculosis (TB), mycobacterial antigen-induced production and plasma levels of the inflammatory cytokine interferon- γ (IFN- γ ) and its regulatory cytokines interleukin-12 (IL-12), IL-18, and IL-10...
Ginseng radix, the dried root of Panax ginseng C. A. Meyer, has been shown to enhance the ability to resist microbial infections. Proinflammatory cytokines, such as tumor necrosis factor- α (TNF- α ), interleukin-1 β (IL-1 β ), IL-6, and interferon- γ (IFN- γ ) are produced by macrophages...
Type I interferons (IFNs) are potent regulators of both innate and adaptive immunity. All type I IFNs bind to the same heterodimeric cell surface receptor composed of IFN- α receptor (IFNAR-1) and IFN- α / β receptor (IFNAR-2) polypeptides. This study revealed that type I IFN receptor levels...
Using oligonucleotide microarrays, we have examined the expression of 22,000 genes in peripheral blood cells treated with pegylated interferon- α 2b (PEG-IFN- α ) and ribavirin. Treatment with ribavirin had very little effect on gene expression, whereas treatment with PEG-IFN- α had a dramatic...
In this report, the mechanism through which interferon- γ (IFN- γ ) regulates the expression of nitric oxide synthase (NOS-1) in neurons was examined. We have shown previously that IFN- γ treatment of cells results in a two log inhibition of vesicular stomatitis virus (VSV) production. This...
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