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Interferon- β (IFN- β ) is biologically unstable under physiologic conditions in vitro and is cleared rapidly from the bloodstream on administration in vivo . In the present study, we demonstrate that a soluble recombinant form of the type I IFN receptor subunit, sIFNAR-2, can neutralize the...
To test the hypothesis that HIV infection brings about an alteration in the immune response to tuberculosis (TB), mycobacterial antigen-induced production and plasma levels of the inflammatory cytokine interferon- γ (IFN- γ ) and its regulatory cytokines interleukin-12 (IL-12), IL-18, and IL-10...
Type I interferons (IFNs) are potent regulators of both innate and adaptive immunity. All type I IFNs bind to the same heterodimeric cell surface receptor composed of IFN- α receptor (IFNAR-1) and IFN- α / β receptor (IFNAR-2) polypeptides. This study revealed that type I IFN receptor levels...
Ginseng radix, the dried root of Panax ginseng C. A. Meyer, has been shown to enhance the ability to resist microbial infections. Proinflammatory cytokines, such as tumor necrosis factor- α (TNF- α ), interleukin-1 β (IL-1 β ), IL-6, and interferon- γ (IFN- γ ) are produced by macrophages...
Using oligonucleotide microarrays, we have examined the expression of 22,000 genes in peripheral blood cells treated with pegylated interferon- α 2b (PEG-IFN- α ) and ribavirin. Treatment with ribavirin had very little effect on gene expression, whereas treatment with PEG-IFN- α had a dramatic...
In this report, the mechanism through which interferon- γ (IFN- γ ) regulates the expression of nitric oxide synthase (NOS-1) in neurons was examined. We have shown previously that IFN- γ treatment of cells results in a two log inhibition of vesicular stomatitis virus (VSV) production. This...
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