Within the last year
Within the past 3 years
1 - 5 of 5 articles
Interferon-γ (IFN-γ) is a key cytokine in the immune defense against mycobacteria. IFN-γ activates macrophages to resist the growth of mycobacteria and induces expression of MHC class II molecules required for antigen presentation. Macrophages infected with mycobacteria or stimulated by the...
Type I interferons (IFNs) include the IFN-α family of subtypes, IFN-β, IFN-ω, IFN-τ, IFN-κ, IFN-λ, and IFN-ζ. IFN genes lack introns and encode secretory signal peptide sequences that are proteolytically cleaved prior to secretion from the cell. In contrast to the approximately 50% amino...
In multiple sclerosis (MS), a crucial step in the induction phase of the inflammatory process in the central nervous system (CNS) is the disruption of the endothelial blood-brain barrier (BBB). Its permeability depends on the expression of intercellular adhesion molecules, such as vinculin and...
Lymphocytes from aged autoimmune MRL/ lpr mice overexpress Fas ligand (FasL), and are cytotoxic against Fas + target cells. This cytotoxic potential is only partly due to FasL, as wild-type MRL +/+ lymphocytes are not able to kill Fas + targets after induction of FasL. In addition, serum levels...
Interleukin-4 (IL-4) can elicit diverse cellular responses, including differentiation, fusion, and proliferation, and these are all critical to establishment of an effective immune response. In this report, we provide evidence that IL-4 induces the proliferation of T lymphocytes with the...
Read and print from thousands of top scholarly journals.
Sign up with Facebook
Sign up with Google
Already have an account? Log in
Save this article to read later. You can see your Read Later on your DeepDyve homepage.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Sign Up Log In
To subscribe to email alerts, please log in first, or sign up for a DeepDyve account if you don’t already have one.
To get new article updates from a journal on your personalized homepage, please log in first, or sign up for a DeepDyve account if you don’t already have one.