Select All | Select None
You can now keep track of new articles from Journal of Interferon and Cytokine Research on your personalized homepage!
Interferons (IFNs) are potent, pleiotropic cytokines, and therefore it is likely that the cell has mechanisms to modulate IFN activity in response to excessive or prolonged IFN exposure. To investigate this question, Jurkat T cells were exposed to IFN- β 1a in vitro . The effect of dose and...
A 2′,5′-oligoadenylate (2-5A)-dependent 37-kDa form of RNase L has been reported in extracts of peripheral blood mononuclear cells (PBMC) from individuals with chronic fatigue syndrome (CFS). In the current study, analytic gel permeation FPLC, azido photoaffinity labeling, two-dimensional...
The aim of this study was to investigate the contribution of endogenous - that is, without the addition of any interferon (IFN) inducer - type I IFN production in the defense against tumor development. To this purpose, the IFN- α receptor (IFNAR) knockout (KO)-induced mutation, resulting in the...
We tested for development of binding and neutralizing antibodies to interferon- α (IFN- α ) during IFN- α 2a therapy of patients with age-related macular degeneration (AMD) of the eyes. Antibodies were investigated retrospectively in sera of 34 patients treated with 3 × 10 6 IU IFN- α 2a...
Chicken anemia virus (CAV) and infectious bursal disease virus (IBDV) are the two most important viruses that cause immunosuppression in commercial chickens. Because inapparent, subclinical infections by these viruses cause immunosuppression, there is need for assessment of the immune status of...
We compared the antigenic properties of human interferon- α 2c (IFN- α 2c), IFN- α 21a, hybrids IFN- α 21a/ α 2c, and their mutants, using a panel of 27 anti-IFN- α 1, anti-IFN- α 2, and anti-IFN- α 8/1/8 monoclonal antibodies (mAb). After immunoanalysis by ELISA, we found parental IFN-...
The skin is the largest organ in the human body. It acts not only as an important structural barrier against injury but also as a peripheral arm of the immune system. Elucidating the characteristics of this latter function has taken on renewed importance in recent years. Exposure to chemicals in...
In patients with chronic hepatitis C, prior studies have suggested that increased hepatic iron concentration (HIC) is predictive of a poor response to interferon (IFN) monotherapy. The aim of this study was to assess the importance of HIC on the virologic response to therapy with IFN alone or...
The function of the common carp, Cyprinus carpio L., interleukin-1 β (IL-1 β ) gene was studied by DNA injection. To investigate the immune responses to IL-1 β , a plasmid construct of cytomegalovirus (CMV)-driven carp IL-1 β was injected into the epaxial muscle of carp. IL-1 β protein...
results per page
Save this article to read later. You can see your Read Later on your DeepDyve homepage.
To save an article, log in first, or sign up for a DeepDyve account if you don't already have one.
Sign Up Log In
To subscribe to email alerts, please log in first, or sign up for a DeepDyve account if you don't already have one.
Read and print from thousands of top scholarly journals.
Sign up with Facebook
Sign up with Google
Already have an account? Log in
To get new article updates from a journal on your personalized homepage, please log in first, or sign up for a DeepDyve account if you don't already have one.