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A 2′,5′-oligoadenylate (2-5A)-dependent 37-kDa form of RNase L has been reported in extracts of peripheral blood mononuclear cells (PBMC) from individuals with chronic fatigue syndrome (CFS). In the current study, analytic gel permeation FPLC, azido photoaffinity labeling, two-dimensional...
Interferons (IFNs) are potent, pleiotropic cytokines, and therefore it is likely that the cell has mechanisms to modulate IFN activity in response to excessive or prolonged IFN exposure. To investigate this question, Jurkat T cells were exposed to IFN- β 1a in vitro . The effect of dose and...
The aim of this study was to investigate the contribution of endogenous - that is, without the addition of any interferon (IFN) inducer - type I IFN production in the defense against tumor development. To this purpose, the IFN- α receptor (IFNAR) knockout (KO)-induced mutation, resulting in the...
We tested for development of binding and neutralizing antibodies to interferon- α (IFN- α ) during IFN- α 2a therapy of patients with age-related macular degeneration (AMD) of the eyes. Antibodies were investigated retrospectively in sera of 34 patients treated with 3 × 10 6 IU IFN- α 2a...
Chicken anemia virus (CAV) and infectious bursal disease virus (IBDV) are the two most important viruses that cause immunosuppression in commercial chickens. Because inapparent, subclinical infections by these viruses cause immunosuppression, there is need for assessment of the immune status of...
We compared the antigenic properties of human interferon- α 2c (IFN- α 2c), IFN- α 21a, hybrids IFN- α 21a/ α 2c, and their mutants, using a panel of 27 anti-IFN- α 1, anti-IFN- α 2, and anti-IFN- α 8/1/8 monoclonal antibodies (mAb). After immunoanalysis by ELISA, we found parental IFN-...
In patients with chronic hepatitis C, prior studies have suggested that increased hepatic iron concentration (HIC) is predictive of a poor response to interferon (IFN) monotherapy. The aim of this study was to assess the importance of HIC on the virologic response to therapy with IFN alone or...
The skin is the largest organ in the human body. It acts not only as an important structural barrier against injury but also as a peripheral arm of the immune system. Elucidating the characteristics of this latter function has taken on renewed importance in recent years. Exposure to chemicals in...
The function of the common carp, Cyprinus carpio L., interleukin-1 β (IL-1 β ) gene was studied by DNA injection. To investigate the immune responses to IL-1 β , a plasmid construct of cytomegalovirus (CMV)-driven carp IL-1 β was injected into the epaxial muscle of carp. IL-1 β protein...
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