New! You can now keep track of new articles from Journal of Interferon and Cytokine Research on your personalized homepage!
Interleukin-2 (IL-2) is the first lymphokine secreted following T cell activation. Several transcription factors regulate IL-2 gene expression, including the nuclear factor of activated T cells (NFAT). NFAT acts at the antigen receptor response element-2 (ARRE-2) sequence in the IL-2 enhancer and...
There is a prerequirement of at least two sets of signals delivered by the antigen-presenting cell (APC) for the optimal activation of T helper (Th) cells. The First signal is provided by the engagement of T cell receptor with the antigen-MHC class II complex, followed by a second stimulus in the...