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Human corneal fibroblasts (HCF) inhibit T cell alloresponse in mixed leukocyte response-human corneal fibroblast coculture. The inhibition is contact independent, insensitive to indomethacin, and is enhanced by pretreatment of HCF with interferon-Î³ (IFN-Î³). To investigate cytokine-dependent...
The interaction between virus and peripheral blood mononuclear cells (PBMC) required to elicit the production of interferon-Î± (IFN-Î±) by the so-called natural interferon-producing cell is unknown. However, results from inhibition experiments suggest that viral glycoproteins are essential in...
The effect of two type 1 interferons (r-metIFN-conl and IFN-Î± 2b ) on tne induction of specific cytokines and IL-1Ra in whole blood was examined. IFN-Î³ was induced at low levels following treatment of diluted whole blood in some but not all subjects. IL-1Ra was induced by both r-metIFN-conl...
Cyclosporin A (CsA) administration reduced mortality in mice sensitized to endotoxic toxicity by various agents, such as muramyl dipeptide (MDP) or a lipophilic derivative. CsA is an inhibitor of a variety of T cell responses, suggesting that muramyl peptides could influence LPS-induced effects...
We studied the antiproliferative effects of human interferon-Î³ (IFN-Î³) on cell lines derived from human carcinomas (three breast, two ovarian, and one renal) and recovery from these effects when IFN-Î³ was removed after 6 or 72 h. IFN-Î³ led to a dose-dependent and time-dependent...
The op/op mouse has a mutation in the macrophage colony-stimulating (CSF-1) gene. The phenotype of gross deficiency in the macrophage and osteoclast lineages corrects significantly with age, suggesting that other factors can substitute for CSF-1. This review examines the evidence that the op/op...
Glycosylation of proteins fulfills important functions and because of its diversity contributes to apparent protein heterogeneity. We investigated the heterogeneity of a fusion protein comprising the extracellular domain of the human interferon-Î³ (IFN-Î³) receptor and parts of the human IgG...
Variants of human leukocyte interferon Î± 2 (IFN-Î± 2a , Î± 2b , and Î± 2c ) differ from each other by changes in their coding regions at nucleotide positions 137 and 170. As a result of these nucleotide variations, the DNA sequences of the three variants can be distinguished by selective...
The T cell antigen receptor complex (CD3/Ti) plays a role in specific antigen recognition as well as in signal transduction, with its surface expression required for the function of several other structurally distinct receptor systems, including CD2, Ly-6(TAP), and Thy-1. In this communication,...
Production of interferon (IFN) in quail cells (QT35) and the activity of quail IFN and heterologous avian IFN (chicken) on QT35 cells were examined. Quail cells produced IFN after induction by bluetongue virus serotype 10; chicken and quail IFN conferred antiviral resistance on the quail cells....
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