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Malignant mesothelioma is an aggressive tumor, usually induced by asbestos exposure, that has a poor prognosis and is unresponsive to conventional therapy. The present study was aimed at assessing the potential for interferon-Î± (IFN-Î±)-based therapies in a murine model for malignant...
MAb IGMB-15, an anti-hIFN-Î³ MAb, neutralizes the antiproliferative activity of hIFN-Î³ without affecting that of hIFN-Î± or hIFN-Î². The neutralizing capacity of MAb IGMB-15 is wide: it has been assessed on cell lines whose origin and sensitivity to hIFN-Î³ differ. The binding of...
A potent, reversible, tetrapeptide inhibitor of interleukin-lÎ² converting enzyme (ICE), L-709,049, has been shown to suppress the in vitro production of mature IL-1Î². We now report that this inhibitor also effectively suppresses the production of mature IL-1Î² in a murine model of...
Interleukin-6 (IL-6) is a cytokine that has been implicated as a growth factor in human ovarian carcinoma, yet the in vivo source of IL-6 in patients remains undefined. We measured IL-6 by ELISA in cell-free ascites (CFA) of 19 patients with ovarian carcinoma. IL-6 was detectable in all samples...
The role of the lungs in the catabolism of rat recombinant interferon-Î³, either in normal rats or in rats subjected to an acute cigarette smoking episode, was evaluated using an isolated and perfused lung preparation. After administration of interferon-Î³ into the lung perfusion medium,...
The antiviral activity of human r-metIFN-con1 was compared with that of IFN-Î± 2a and IFN-Î² on a number of human, other primate, rodent, feline, and canine cell lines. Although the specific activities of r-metIFN-con 1 and IFN-Î³ 2a differed 10-fold, the host range was very similar. The...
The influence of CSF therapy on the Superoxide (O 2 - ) releasing capacity in response to N -formyl-methionylleucyl-phenylalanine (FMLP) of neutrophils from 32 patients with testicular cancer receiving high-dose chemotherapy followed by autologous bone marrow transplantation (ABMT) was assessed:...
Two monoclonal antibodies that recognize different epitopes of the extracellular domain of one of the proteins that constitute the type I interferon receptor were used to delineate the interferon binding site. Antibody 64G12 both inhibits the binding of radiolabeled interferon-Î± 2 and IFN-Î±...
Cytokine expression was examined by reverse transcriptase-polymerase chain reaction (RT-PCR) in a retrospective sampling of 16 AIDS-associated large cell lymphomas (LCL). IL-6 receptor (IL-6R) and IL-10 expression was detected in a majority of the tumor specimens tested. IL-6 expression was...
Children or adults with the primary immunodeficiency disease, common variable immunodeficiency (CVI), have abnormally low levels of at least two of the three serum Ig isotypes. Although there appear to be intrinsic B cell defects, many have poor T cell proliferation and deficient secretion of...
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