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Optimal therapy for acne vulgaris depends upon a knowledge of the basic pathogenic mechanisms of the disease. In this introductory report, the four basic goals of treatment are briefly summarized and some of the unsolved problems related to the pathogenesis of acne have been brought up for...
Azelaic acid is now an established therapeutic agent for acne vulgaris, where its antibacterial and comedolytic activity is responsible in the main for its beneficial effects. In this report we describe the results of a single-centre double-blind controlled contralateral split-face study of the...
Azelaic acid (AZA) is an endogenous C9-dicarboxylic acid synthesized by omega-oxidation from fatty acids and found as a physiological component in human urine. After topical application, about 3.6% is absorbed through the skin. AZA is metabolized via the β-oxidation pathway ending in the...
Azelaic acid has been shown to be an effective topical acne therapy. Cream containing 20% azelaic acid significantly reduces the skin surface and follicular propionibacteria and staphylococci by at least 96% after 8 weeks of treatment. In vitro, azelaic acid reduces the growth rate of, and...
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