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10.1002/jcb.240350106.abs The secondary activation of the avian vitellogenin II gene in isolated liver nuclei by cytoplasmatic liver extracts of estradiol‐treated chicks is accompanied by the binding of a protein from the extract to the structural part of the cloned gene. Both the DNA‐binding...
10.1002/jcb.240350104.abs We have examined the nature of biochemical degradation of an isolated basement membrane matrix (bovine lens capsule) using different methodologies. The first strategy was quantitation of the release of surface‐bound 125I and a second the documentation by SDS‐PAGE of...
10.1002/jcb.240350105.abs This brief review explores some recent observations relating to the structure of untransformed glucocorticoid and progesterone receptors and the mechanism by which the receptors are transformed to the DNA‐binding state. In their molybdate‐stabilized, untransformed...
10.1002/jcb.240350103.abs In an attempt to understand the mechanism by which estrogens stimulate cell proliferation and mammary carcinogenesis, metastatic human breast cancer cell lines (MCF7, ZR75‐1) were found to secrete a 52,000 dalton (52K) protein under estrogen stimulation. Following its...
10.1002/jcb.240350102.abs We describe studies on human breast cancer in which it is shown that specific growth factors (IGF‐I, TGFα, PDGF) are secreted by human breast cancer cells and likely to be involved in tumor growth and progression. These activities are regulated by estradiol in...
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