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You can now keep track of new articles from Journal of Biomolecular Screening on your personalized homepage!
Microorganisms were among the first tools used for the discovery of biologically active compounds. Their utility reached a zenith during the era of antibiotic development in the 1950s and 1960s, then declined. Subsequently, a substantial role for microorganisms in the pharmaceutical industry...
Membranes prepared from stable transfected cells expressing the human gene encoding a functional 5-hydroxytryptaminelE (5HT1E) receptor were used to investigate high-affinity 3 Hserotonin ( 3 H5-HT) binding with scintillation proximity assay (SPA) technology. In this nonseparation format,...
We have developed a scintillation proximity assay (SPA) that allows the Ca 2+ /calmodulin (CaM)-dependent Serine/threoine (Ser/Thr) phosphoprotein phosphatase 2B (calcineurin) activity to be analyzed. A 33 P labeled and biotinylated peptide containing a partial sequence of the regulatory subunit...
Activation of p34 cdc2 requires a complex series of protein/protein interactions and specific phosphorylation and de-phosphorylation events to occur. The cellular role of p34 cdc2 kinase lies in the regulation of eukaryotic cell entry into mitosis, in particular into the G 2 /M transition. This...
Binding of a protein at a ligand-modified ion channel can lead to closure or distortion of the channel, resulting in a digital on/off response of the ion flux. This principle could be applied as a strategy for sensor design using artificial membrane ligands or receptors. Important details of...
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