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In vivo, neurons form neurites, one of which develops into the axon while others become dendrites. While this neuritogenesis process is well programmed in vivo, there are limited methods to control the number and location of neurite extension in vitro. Here we report a method to control...
The demanding need for tissue replacement resulted in manifold approaches for the construction of different tissues. One common problem which hampers the clinical usage of tissue engineering constructs is a limited vascularization. In an attempt to accelerate the vascularization of tissue...
The additive manufacturing technique selective laser melting (SLM) has been successfully proved to be suitable for applications in implant manufacturing. SLM is well known for metal parts and offers direct manufacturing of three‐dimensional (3D) parts with high bulk density on the base of...
In this study, hydrophilic PLGA/Pluronic F127 scaffolds loaded with a pDNA/PEI‐PEG complex were prepared to estimate their potential use as a polymeric matrix for pDNA delivery. The scaffold was fabricated by a novel precipitation/particulate leaching method. The prepared pDNA/PEI‐PEG...
Folate (FA)‐conjugated star‐shaped copolymer was prepared as a targeted carrier for anticancer drug delivery by ring‐opening polymerization of L‐lactide using pentaerythritol (PTL) as an initiator, followed by conjugation with methoxy poly(ethylene glycol) (MPEG) and FA‐poly(ethylene...
Reaming debris is formed when bone defects are stabilized with an intramedullary nail, and contains viable osteoblast‐like cells and growth factors, and might thus act as a natural osteoinductive scaffold. The advantage of using reaming debris over stem cells or autologous bone for healing bone...
Silk scaffolds have been successfully used for a variety of tissue engineering applications due to their biocompatibility, diverse physical characteristics, and ability to support cell attachment and proliferation. Our prior characterization of 4‐day postnatal rat tooth bud cells grown on...
Biomaterials used in regenerative medicine are often designed to act as 3D porous templates (scaffolds) able to support and promote the growth and repair of natural tissues. Some types of glasses have a great potential for making bone tissue engineering scaffolds, as they can bond to host bone,...
The present study was conducted to histologically and histomorphometrically evaluate the application of cancellous bone‐block allografts for the augmentation of the posterior atrophic mandible. Twenty‐four consecutive patients underwent augmentation with cancellous bone‐block allografts in...
Biomaterials are becoming increasingly popular for use in spinal cord repair, but few studies have investigated their long‐term biocompatibility in central nervous system tissue. In this study, chitosan was compared with two commercial materials, degradable polyglycolide (vicryl and polyglactin...
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